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Bupropion HCl was initially developed to improve on the safety and tolerability of existing antidepressants1 It is the only antidepressant available with a dual effect on norepinephrineNEand dopamineDAneuro-transmitter systems2 Bupropion was initially marketed as an immediate-releaseIRproducta sustained-releaseSRformulation was approved in 1996and in August 2003a once-daily extended-releaseXLformulation became available3 Bupropion is now approved for use in over 50 countries for the treatment of major depressive disorder and/or as an aid to smoking cessationwith over 40 million patients receiving treatmentdata on fileGlaxoSmithKlineResearch Triangle ParkN.COn the 15th anniversary of the introduction of bupropionthis review was developed to provide an overview of bupropion HCl that encompasses the compound’s background and historymechanism of actiondistinct formulationsand clinical profileMajor efficacy trials and other reports were obtained and reviewed from MEDLINE searchesreview of abstracts from professional meetingsand the bupropion SR manufacturer’s databasesSearches of English-language articles were conducted from June 2003 through August 2004No time limit was specified in the searcheswhich were conducted using the search terms bupropionbupropion SRand bupropion XL

Common1to 10Bronchitiscoughdyspnea/shortness of breathepistaxisincreased coughsinusitisupper respiratory tract infection.

In clinical trials with the immediate-release formulation of bupropion10of patients and volunteers discontinued due to an adverse eventEvents resulting in discontinuationin addition to those listed above for the sustained-release formulation of bupropioninclude vomitingseizuresand sleep disturbances.

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