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If you are pregnantplanning to become pregnantor are breast-feeding if you are taking any prescription or nonprescription medicineherbal preparationor dietary supplement if you have allergies to medicinesfoodsor other substances if you have a history of heart problemsegcongestive heart failurecor pulmonalean irregular heartbeatliver problemsegcirrhosishepatitisviral infectionthyroid problemsincreased acid levels in the bodybrain or nerve problemsor seizuresegepilepsyif you are in shock or have a feveran ulcera severe infectioncystic fibrosisor fluid in the lungspulmonary edemaif you smokeare stopping or starting smokingor are exposed to the smoke from cigarettes or marijuana if you are in the last 3 months of pregnancy.
Long term carcinogenicity studies have been carried out in miceoral doses 30-150 mg/kgand ratsoral doses 5-75 mg/kgResults are pending.
Administer multiple-dose oral activated charcoal and measures to control emesis.
Severe toxicity from theophylline overdose is a relatively rare eventIn one health maintenance organizationthe frequency of hospital admissions for chronic overdosage of theophylline was about 1 per 1000 person-years exposureIn another studyamong 6000 blood samples obtained for measurement of serum theophylline concentrationfor any reasonfrom patients treated in an emergency department7were in the 20-30 mcg/mL range and 3were30 mcg/mLApproximately two-thirds of the patients with serum theophylline concentrations in the 20-30 mcg/mL range had one or more manifestations of toxicity while90of patients with serum theophylline concentrations30 mcg/mL were clinically intoxicatedSimilarlyin other reportsserious toxicity from theophylline is seen principally at serum concentrations30 mcg/mL.
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