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Morphine triggered naltrexone delivery

The blockade of opioid receptors is the basis behind naltrexone s action in the management of opioid dependence it reversibly blocks or attenuates the effects of opioids.

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Patients with addictive disordersespecially opioid addictionare at risk for multiple numerous adverse events and abnormal laboratory findingsincluding liver function abnormalitiesData from both controlled and observational studies suggest that these abnormalitiesother than the dose-related hepatotoxicity described aboveare not related to the use of REVIA.

Alcohol-and opioid-dependent patientsincluding those taking REVIAshould be monitored for the development of depression or suicidal thinkingFamilies and caregivers of patients being treated with REVIA should be alerted to the need to monitor patients for the emergence of symptoms of depression or suicidalityand to report such symptoms to the patient’s healthcare provider.

PO25 mg initiallythen observation for 1 hrthen 50 mg once daily starting on day 2flexible dosing regimens can be employed to accommodate patient convenience or ensure compliance.

The administration of REVIA is not associated with the development of tolerance or dependenceIn subjects physically dependent on opioidsREVIA will precipitate withdrawal symptomatology.

Duramed PharmaceuticalsIncSubsidiary of Barr PharmaceuticalsIncPomonaNew York 10970Revised10/2013.

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high dose opioid intake, concomitant with naltrexone treatment, can lead to life-threatening opioid poisoning from respiratory and circulatory impairment.

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