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After oral dosing of terazosin AUC and C max increase in proportion with dose over the recommended dose range2-10 mg
Musculoskeletal complaints of pain or cold extremities have been reported in up to 17and 12of patientsrespectivelyRef]
If you stop taking Hytrin for any reasoncall your doctor before you start taking it againYou may need a dose adjustment.
Terazosin has been extensively studied in 1222 men with symptomatic BPHIn three placebo-controlled studiessymptom evaluation and uroflowmetric measurements were performed approximately 24 hours following dosingSymptoms were systematically quantified using the Boyarsky IndexThe questionnaire evaluated both obstructivehesitancyintermittencyterminal dribblingimpairment of size and force of streamsensation of incomplete bladder emptyingand irritativenocturiadaytime frequencyurgencydysuriasymptoms by rating each of the 9 symptoms from 0-3for a total score of 27 pointsResults from these studies indicated that terazosin statistically significantly improved symptoms and peak urine flow rates over placebo as follows:
1mg before bedtime is the starting dose for all patients and should not be exceededStrict compliance with this recommendation should be observed to minimise acute first-dose hypotensive episodes.
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