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In healthy subjects given single 500 mg doses of cephalexin and metforminplasma metformin mean C max and AUC increased by an average of 34and 24respectivelyand metformin mean renal clearance decreased by 14No information is available about the interaction of cephalexin and metformin following multiple doses of either drug.
KEFLEX is indicated for the treatment of bone infections caused by susceptible isolates of Staphylococcus aureus and Proteus mirabilis
Keflex is indicated for the treatment of skin and skin structure infections caused by susceptible isolates of the following Gram-positive bacteriaStaphylococcus aureus and Streptococcus pyogenes
There are no adequate and well-controlled studies in pregnant womenBecause animal reproduction studies are not always predictive of human responsethis drug should be used during pregnancy only if clearly needed.
Careful patient monitoring and dose adjustment of metformin is recommended in patients concomitantly taking Keflex and metforminsee Clinical Pharmacology12.2
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