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The total daily dose of viramune did not exceed 400 mg in either regimen.

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Twenty per cent of patients assigned to nevirapine twice daily and 18of patients assigned to efavirenz had at least one grade 3 or 4 clinical adverse eventClinical hepatitis reported as clinical adverse event occurred in 102.6and 20.5patients in the nevirapine twice daily and efavirenz groups respectivelyThe proportion of patients with at least one grade 3 or 4 liver-associated laboratory toxicity was 8.3for nevirapine twice daily and 4.5for efavirenzOf the patients with grade 3 or 4 liver-associated laboratory toxicitythe proportions coinfected with hepatitis B or hepatitis C virus were 6.7and 20.0in the nevirapine twice daily group5.6and 11.1in the efavirenz group.

Initial therapyWhen initiating therapygive immediate-release tablet 200 mg PO qDay for 14 daysthen extended-release tablet 400 mg PO qDay thereafter Switch from immediate-releaseIf already taking immediate-release regimenmay switch to extended-release 400 mg PO qDay without 14-day lead-in period of immediate-release nevirapine.

Viramune is an antiviral medicineIt is used in combination with other antiviral medicines to treat patients infected with human immunodeficiency virus type 1HIV-1a virus that causes acquired immune deficiency syndromeAIDS

Any patient experiencing severe rash or a rash accompanied by constitutional symptoms such as feverblisteringoral lesionsconjunctivitisfacial oedemamuscle or joint achesor general malaise should discontinue the medicinal product and immediately seek medical evaluationIn these patients nevirapine must not be restarted.

Howeverapproximately 15of these patients with hepatic fibrosis had nevirapine trough concentrations above 9,000 ng/ml2 fold the usual mean troughPatients with hepatic impairment should be monitored carefully for evidence of medicinal product induced toxicity.

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About Satyam

Born and Bred in Lakhimpur, Enjoys working at his own pace. Techno geek, tequila and House music make him tick. Loves to explore new places and cuisines.

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