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The mean pharmacokinetic parameters for Rand S-oxybutynin are summarized in Table 1The plasma concentration-time profiles for Rand S-oxybutynin are similar in shapeFigure 1 shows the profile for R-oxybutynin.
A 24-month study in rats at dosages of oxybutynin chloride of 2080and 160 mg/kg/day showed no evidence of carcinogenicityThese doses are approximately 625and 50 times the maximum human exposurebased on surface area.
Ditropan XLoxybutyninreduces muscle spasms of the bladder and urinary tract.
Reproduction studies using oxybutynin chloride in the hamsterrabbitratand mouse have shown no definite evidence of impaired fertility.
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